You won't be able to catch the response on the bulk email using the signal process element (since this data is added to the database directly) however you can create a process with the timer that will review the "Response in Email" object and check if a new "Unsubscribe" response was added. You can create a time parameter and use it as a filtration condition (in the "Created On" field). So you can run this process once per hour, read the collection of records in the process (from the "Response in Email" object) and use this data.
You won't be able to catch the response on the bulk email using the signal process element (since this data is added to the database directly) however you can create a process with the timer that will review the "Response in Email" object and check if a new "Unsubscribe" response was added. You can create a time parameter and use it as a filtration condition (in the "Created On" field). So you can run this process once per hour, read the collection of records in the process (from the "Response in Email" object) and use this data.